PEMBUATAN GEL ANTIBAKTERI DARI EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP BAKTERI PROPOINIBACTERIUM ACNES
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Muhartri Sanjaya
Arsiaty Sumule
Yulia Delfahedah
Dilla Sastri Mara
Wilson Samosir
Latar belakang: Salah satu tanaman yang bisa dijadikan tumbuhan obat adalah daun pepaya. Tanaman pepaya (Carica papaya L.) merupakan tanaman yang mudah tumbuh di dataran rendah maupun dataran tinggi, banyak dijumpai di Indonesia sebagai tanaman kaya manfaat. Tanaman pepaya memiliki banyak manfaat mulai dari bagian akar,batang, daun, bunga, dan buahnya, yaitu sebagai sumber vitamin, mineral dan senyawa lainnya untuk kebugaran tubuh dan berkhasiat obat dalam bidang kesehatan. Daun yang dimakan langsung setelah dimasak diyakini memperkuat sekresi empedu, obat mulas, sariawan, beri-beri, asma, jerawat, obat cacing kremi, memperbaiki pencernaan, menambah nafsu makan serta bersifat antibakteri dan antiseptik (Ruswanti et el., 2014). Tujuan: Penelitian ini bertujuan untuk mengetahui apakah ektrak daun pepaya dapat diformulasikan dalam bentuk sediaan gel obat antibakteri terhadap bakteri propionibacterium acnes. Metode: Pembuatan ekstrak daun pepaya menggunakan metode maserasi dengan etanol 96% sebagai pelarut. Maserat diuapkan hingga diperoleh ekstrak 250 mg. Pengujian antibakteri dengan metode difusi agar menggunakan pencadang kertas, dilakukan uji bakteri Propionibacterium acne. Pembuatan formula ekstrak etanol daun pepaya menggunakan basis gel dengan konsentrasi ekstrak 5% mempunyai formula yang hasil mempunyai pH 8. Pengujian uji aktivitas antibakteri basis gel terhadap Propionibacterium acne mempunyai daya hambat 7 mm, sedangkan formula yang mengandung ekstrak ± 15,3mm. Hasil: Hasil penelitian menunjukkan bahwa ekstrak etanol 96% daun pepaya memiliki aktivitas antibakteri dari ekstrak etanol pada propionibacterium acnes. Kesimpulan: Bahwa formulasi gel ekstrak etanol daun pepaya pada konsentrasi 5% sudah mempunyai aktivitas yang baik.
Anonim. Kandungan Kimia Daun Pepaya. http://digilib.unimus.ac.id/files/ disk1/146/jtptunimus-gdl-mohsafiqa-7277-3-ba-bii.pdf
Depkes RI. 2000. Parameter standar umum ekstrak tumbuhan obat. Edisi I. Jakarta: Departemen kesehatan Republik Indonesa. Halaman 9-12.
Dini Nuris Nuraini, S.Si. (2007). Daun Berkhasiat Obat. Gava Media. Yogyakarta.
Dwidjoseputro. (2005). Dasar-dasar Mikrobiologi, Djambatan,. Jakarta.
Eko Wahyu Soranta. (2009). Aktifitas antibakteri ekstrak daun pepaya (Carica papaya L.) Terhadap Escherichia coli Dan Staphylococcus aureus Multiresisten Antibiotik. Skripsi. Fakultas Farmasi. Universitas Muhammadiyah. Surakarta. 8 Maret 2016.
Sugiono. 2013. Metode Penelitian Alfabeta. Bandung
Depkes RI. 1995. Farmakope Indonesia. Edisi keempat. Jakarta: Departemen Kesehatan RI.Halaman 854-855,891.
Draelos, Z. D., dan Lauren A. T. (2006). Cosmetic Formulation of skin care product. New York: Taylor and Francis Group. Halaman 11.
Tjitrosoepomo, G. (2005). Morfologi Tumbuhan. Yogyakarta:Gajah Mada, University Press. Halaman 182.
Tranggono, R.I, dan Latifah, F. (2007). Buku pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT. Gramedia Pustaka Utama. Halaman 4.
Anief, M. (2006). Ilmu Meracik Obat. Edisi ketiga belas. Yogyakarta: Gajah Mada Universsity press. Halaman 71-73.
Robinson, T. 1995. Kandungan Organik Tumbuhan Tinggi. Edisi Ke-4 Terjemahkan Kosasi Padmawinata. ITB Press. Bandung
Pratiwi, ST. (2008). Mikrobiologi Farmasi. Yogyakarta: Penerbit Erlangga. Halaman 176
Harborne, J.B. 1996. Metode Fitokimia: Penuntun Cara Modern Menganalisa Tumbuhan . Terbitan Kedua. ITB. Bandung. Hal: 123-129
Nur Ilham, R. ., Arliansyah, A., Juanda, R., Multazam, M. ., & Saifanur, A. . (2021). RELATHIONSIP BETWEEN MONEY VELOCITY AND INFLATION TO INCREASING STOCK INVESTMENT RETURN: EFFECTIVE STRATEGIC BY JAKARTA AUTOMATED TRADING SYSTEM NEXT GENERATION (JATS-NG) PLATFORM. International Journal of Economic, Business, Accounting, Agriculture Management and Sharia Administration (IJEBAS), 1(1), 87–92. https://doi.org/10.54443/ijebas.v1i1.27
Yusuf Iis, E., Wahyuddin, W., Thoyib, A., Nur Ilham, R., & Sinta, I. (2022). THE EFFECT OF CAREER DEVELOPMENT AND WORK ENVIRONMENT ON EMPLOYEE PERFORMANCE WITH WORK MOTIVATION AS INTERVENING VARIABLE AT THE OFFICE OF AGRICULTURE AND LIVESTOCK IN ACEH. International Journal of Economic, Business, Accounting, Agriculture Management and Sharia Administration (IJEBAS), 2(2), 227–236. https://doi.org/10.54443/ijebas.v2i2.191
Geovani, I. ., Nurkhotijah, S. ., Kurniawan, H. ., Milanie, F., & Nur Ilham, R. . (2021). JURIDICAL ANALYSIS OF VICTIMS OF THE ECONOMIC EXPLOITATION OF CHILDREN UNDER THE AGE TO REALIZE LEGAL PROTECTION FROM HUMAN RIGHTS ASPECTS: RESEARCH STUDY AT THE OFFICE OF SOCIAL AND COMMUNITY EMPOWERMENT IN BATAM CITY. International Journal of Educational Review, Law And Social Sciences (IJERLAS), 1(1), 45–52. https://doi.org/10.54443/ijerlas.v1i1.10
Bustani, B., Khaddafi, M. ., & Nur Ilham, R. (2022). REGIONAL FINANCIAL MANAGEMENT SYSTEM OF REGENCY/CITY REGIONAL ORIGINAL INCOME IN ACEH PROVINCE PERIOD YEAR 2016-2020. International Journal of Educational Review, Law And Social Sciences (IJERLAS), 2(3), 459–468. https://doi.org/10.54443/ijerlas.v2i3.277
Nur Ilham, R., Heikal, M. ., Khaddafi, M. ., F, F., Ichsan, I., F, F., Abbas, D. ., Fauzul Hakim Hasibuan, A. ., Munandar, M., & Chalirafi, C. (2021). Survey of Leading Commodities Of Aceh Province As Academic Effort To Join And Build The Country. IRPITAGE JOURNAL, 1(1), 13–18. https://doi.org/10.54443/irpitage.v1i1.19
Nur ilham, R., Likdanawati, L., Hamdiah, H., Adnan, A., & Sinta, I. . (2022). COMMUNITY SERVICE ACTIVITIES “SOCIALIZATION AVOID STUDY INVESTMENT” TO THE STUDENT BOND OF SERDANG BEDAGAI. IRPITAGE JOURNAL, 2(2), 61–64. https://doi.org/10.54443/irpitage.v2i2.312
Falahuddin, F., Fuadi, . F., Munandar, M., Juanda, R. ., & Nur Ilham, R. . (2022). INCREASING BUSINESS SUPPORTING CAPACITY IN MSMES BUSINESS GROUP TEMPE BUNGONG NANGGROE KERUPUK IN SYAMTALIRA ARON DISTRICT, UTARA ACEH REGENCY. IRPITAGE JOURNAL, 2(2), 65–68. https://doi.org/10.54443/irpitage.v2i2.313
Majied Sumatrani Saragih, M. ., Hikmah Saragih, U. ., & Nur Ilham, R. . (2021). RELATIONSHIP BETWEEN MOTIVATION AND EXTRINSIC MOTIVATION TO ICREASING ENTREPRENEURSHIP IMPLEMENTATION FROM SPP AL-FALAH GROUP AT BLOK 10 VILLAGE DOLOK MASIHUL. MORFAI JOURNAL, 1(1), 1–12. https://doi.org/10.54443/morfai.v1i1.11
Sandi, H. ., Afni Yunita, N. ., Heikal, M. ., Nur Ilham, R. ., & Sinta, I. . (2021). RELATIONSHIP BETWEEN BUDGET PARTICIPATION, JOB CHARACTERISTICS, EMOTIONAL INTELLIGENCE AND WORK MOTIVATION AS MEDIATOR VARIABLES TO STRENGTHENING USER POWER PERFORMANCE: AN EMPERICAL EVIDENCE FROM INDONESIA GOVERNMENT. MORFAI JOURNAL, 1(1), 36–48. https://doi.org/10.54443/morfai.v1i1.14
Sinurat, M. ., Heikal, M. ., Simanjuntak, A. ., Siahaan, R. ., & Nur Ilham, R. . (2021). PRODUCT QUALITY ON CONSUMER PURCHASE INTEREST WITH CUSTOMER SATISFACTION AS A VARIABLE INTERVENING IN BLACK ONLINE STORE HIGH CLICK MARKET: Case Study on Customers of the Tebing Tinggi Black Market Online Store. MORFAI JOURNAL, 1(1), 13–21. https://doi.org/10.54443/morfai.v1i1.12
Ilham, Rico Nur. et all (2019). Investigation of the Bitcoin Effects on the Country Revenues via Virtual Tax Transactions for Purchasing Management. International Journal of Suplly Management.Volume 8 No.6 December 2019.
Ilham, Rico Nur. et all (2019).. Comparative of the Supply Chain and Block Chains to Increase the Country Revenues via Virtual Tax Transactions and Replacing Future of Money. International Journal of Suplly Management.Volume 8 No.5 August 2019.
Lasta Irawan, A. ., Briggs, D. ., Muhammad Azami, T. ., & Nurfaliza, N. (2021). THE EFFECT OF POSITION PROMOTION ON EMPLOYEE SATISFACTION WITH COMPENSATION AS INTERVENING VARIABLES: (Case Study on Harvesting Employees of PT. Karya Hevea Indonesia). International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET), 1(1), 11–20. https://doi.org/10.54443/ijset.v1i1.2
Rahmaniar, R., Subhan, S., Saharuddin, S., Nur Ilham, R. ., & Anwar, K. . (2022). THE INFLUENCE OF ENTREPRENEURSHIP ASPECTS ON THE SUCCESS OF THE CHIPS INDUSTRY IN MATANG GLUMPANG DUA AND PANTON PUMP. International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET), 1(7), 337–348. https://doi.org/10.54443/ijset.v1i7.36
likdanawati, likdanawati, Yanita, Y., Hamdiah, H., Nur Ilham, R., & Sinta, I. (2022). EFFECT OF ORGANIZATIONAL COMMITMENT, WORK MOTIVATION AND LEADERSHIP STYLE ON EMPLOYEE PERFORMANCE OF PT. ACEH DISTRIBUS INDO RAYA. International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET), 1(8), 377–382. https://doi.org/10.54443/ijset.v1i8.41
Nur Ilham, R., Arliansyah, A., Juanda, R. ., Sinta, I. ., Multazam, M. ., & Syahputri, L. . (2022). APPLICATION OF GOOD CORPORATE GOVERNANCE PRINCIPLES IN IMPROVING BENEFITS OF STATE-OWNED ENTERPRISES (An Emperical Evidence from Indonesian Stock Exchange at Moment of Covid-19). International Journal of Economic, Business, Accounting, Agriculture Management and Sharia Administration (IJEBAS), 2(5), 761–772. https://doi.org/10.54443/ijebas.v2i5.410
Rico Nur Ilham, Irada Sinta, & Mangasi Sinurat. (2022). THE EFFECT OF TECHNICAL ANALYSIS ON CRYPTOCURRENCY INVESTMENT RETURNS WITH THE 5 (FIVE) HIGHEST MARKET CAPITALIZATIONS IN INDONESIA. Jurnal Ekonomi, 11(02), 1022–1035. Retrieved from http://ejournal.seaninstitute.or.id/index.php/Ekonomi/article/view/481
Nur ilham, R., Likdanawati, L., Hamdiah, H., Adnan, A., & Sinta, I. . (2022). COMMUNITY SERVICE ACTIVITIES “SOCIALIZATION AVOID STUDY INVESTMENT” TO THE STUDENT BOND OF SERDANG BEDAGAI. IRPITAGE JOURNAL, 2(2), 61–64. https://doi.org/10.54443/irpitage.v2i2.312
Wayan Mertha, I. ., & Mahfud, M. (2022). HISTORY LEARNING BASED ON WORDWALL APPLICATIONS TO IMPROVE STUDENT LEARNING RESULTS CLASS X IPS IN MA AS’ADIYAH KETAPANG. International Journal of Educational Review, Law And Social Sciences (IJERLAS), 2(5), 507–612. https://doi.org/10.54443/ijerlas.v2i5.369
Mahfud, M., Yudiana, I. K., & Sariyanto, S. (2022). HISTORY OF BANYUWANGI KALIKLATAK PLANTATION AND ITS IMPACT ON SURROUNDING COMMUNITIES. International Journal of Educational Review, Law And Social Sciences (IJERLAS), 3(1), 91–104. https://doi.org/10.54443/ijerlas.v3i1.492
Mahfud et all (2021). PEMANFAATAN TRADISI RESIK LAWON SUKU USING SEBAGAI SUMBER BELAJAR SEJARAH LOKAL PADA SMA DI BANYUWANGI. Media Bina Ilmiah Vol.16 No.3 Oktober 2021. http://ejurnal.binawakya.or.id/index.php/MBI/article/view/1294/pdf
Sinta, I., Nur Ilham, R. ., Authar ND, M. ., M. Subhan, & Amru Usman. (2022). UTILIZATION OF DIGITAL MEDIA IN MARKETING GAYO ARABICA COFFEE. IRPITAGE JOURNAL, 2(3), 103–108. https://doi.org/10.54443/irpitage.v2i3.467
Nur Ilham, R., Arliansyah, A., Juanda, R. ., Sinta, I. ., Multazam, M. ., & Syahputri, L. . (2022). APPLICATION OF GOOD CORPORATE GOVERNANCE PRINCIPLES IN IMPROVING BENEFITS OF STATE-OWNED ENTERPRISES (An Emperical Evidence from Indonesian Stock Exchange at Moment of Covid-19). International Journal of Economic, Business, Accounting, Agriculture Management and Sharia Administration (IJEBAS), 2(5), 761–772. https://doi.org/10.54443/ijebas.v2i5.410
Mahfud et all (2020). Developing a Problem-Based Learning Model through E-Learning for Historical Subjects to Enhance Students Learning Outcomes at SMA Negeri 1 Rogojampi. IOP Conf. Series: Earth and Environmental Science 485 (2020) 012014 https://doi:10.1088/1755-1315/485/1/012014
